Masters moments: Nick Faldo overcomes six-shot deficit to beat Greg Norman in 1996 | Golf News

first_img Faldo's closing 67 piled the pressure on the Australian Faldo's closing 67 piled the pressure on the Australian

Sam Darnold, Cam Newton, Jimmy Garoppolo: What next for NFL’s uncertain crop of quarterbacks? | NFL News

first_img Former NFL coach Rob Ryan tells NFL Overtime that the Cowboys will struggle to replace Dak Prescott after his season-ending ankle injury Prescott was playing under the franchise tag in 2020, with the Cowboys seemingly unwilling to commit to a long-term, big-money deal; Prescott was playing at an MVP level, throwing for 1,856 and nine TDs through five games before being struck down by a devastating ankle injury and Dallas have not won since.Reinebold: “When you talk about the league’s ‘Most Valuable Player’, how valuable was Dak Prescott to the Cowboys? This year is really showing that.“I think Jerry Jones is absolutely out of his mind if he doesn’t give Dak a long-term contract.Ryan Fitzpatrick (Miami Dolphins)Fitzpatrick, a 37-year-old veteran who has played for eight different teams, was always seen as a placeholder in Miami before handing over the reins to rookie Tua Tagovailoa, but he impressed in his six starts to open the season, leading them to a 3-3 record.Young: “I think he’ll be a coach one day in the NFL. He is a very smart guy; I had the opportunity to play with him in Buffalo.“He and coach [offensive coordinator] Chan Gailey are really good friends, and so I’m pretty sure he’ll be on that or some coaching staff one day.”Matt Ryan (Atlanta Falcons) Listen to the Inside The Huddle podcast in the player below, as former Tennessee Titans quarterback Vince Young joins Jeff Reinebold and Neil Reynolds to lend his expertise on the position.They cast their eye over the two young QBs struggling in New York, the Nick Foles/Mitch Trubisky dilemma in Chicago and whether or not Dak Prescott and Cam Newton can earn new contracts…Cam Newton (New England Patriots) Will the winless New York Jets stick with young quarterback Sam Darnold beyond this season? 2:08 Relive some of Nick Foles’ best throws in his first win as a starter for Chicago after the Bears secured a hard-fought 20-19 win over the Buccaneers 2:20 Former NFL coach Rob Ryan tells NFL Overtime that the Cowboys will struggle to replace Dak Prescott after his season-ending ankle injury Cam Newton got off to a good start in New England, winning two of their first three games, but has struggled since 0:48 In an amazing play, Daniel Jones ran 80 yards, destined for a touchdown, only to trip himself up just shy of the endzone Quarterback Matt Ryan sprinted into the edzone for a touchdown in Atlanta’s Week Eight win over Carolina Ryan currently leads the NFL in passing yards (2,462) through the first eight weeks of the season and is on course for a 10th-straight 4,000 yard year, but the Falcons have disappointed as a team, returning a 2-6 record.Reinebold: “When we talk about quarterbacks on this list, it’s about where are you going to get better than what you’ve got? Is Trevor Lawrence going to be better? Maybe, but there’s only one of him in the [2021] Draft.“When you look also at the likes of Kirk Cousins, Matt Ryan, and even Mitch Trubisky and Nick Foles, are you going to be able to find a better quarterback in the draft?“Until you throw away a Matt Ryan, you better make sure you’ve got somebody better lined up.“Historically, drafting quarterbacks is a 50/50 proposition, at best.”Jimmy Garoppolo/Baker Mayfield (San Francisco 49ers/Cleveland Browns) With the usual suspects of Patrick Mahomes, Russell Wilson, Tom Brady and company leading the way in the quarterback position at the midway point of the NFL season, Inside The Huddle looked at players in the position with a more uncertain future.- Advertisement – Relive some of Nick Foles’ best throws in his first win as a starter for Chicago after the Bears secured a hard-fought 20-19 win over the Buccaneers Chicago opened the season with Trubisky – the No 2 overall pick in the 2017 Draft – as their starter, but he was replaced by former Super Bowl MVP Foles in just the third game of the season; the Bears are currently 5-3.Young: “You want to be around a veteran quarterback to help guide you. Trubisky never really had that – he was thrown into the fire pretty quick – and, to me, I think he has the potential to be a really good quarterback.“He has some things he has to work on behind the scenes, and why not learn from a guy like Foles, who has always been that second-string quarterback.“Foles has always been patient. That can help Trubisky understand that this game is not about just a first-string quarterback, because he can go down at any moment – it’s about staying ready, staying prepared, stay focussed.“I think that’s good for him going into the future, with the Bears or be that somewhere else.”Reinebold: “The Bears have so much money tied up into the quarterback position right now, that it’s going to be really difficult to improve their football team.“If you look at the Bears, QB is only one of the problems they have; they don’t have a running game and the offensive line has been problematic for two years now, they don’t have enough dynamic weapons on the outside, nor an elite-level tight end.“The teams that are winning are loaded with talent and the Bears are talent-deficient. It may be a situation where they have to blow the thing up and start again.”Sky Sports NFL is your dedicated channel for NFL coverage through the season – featuring a host of NFL Network programming, a new weekly preview show as well as at least five games a week and NFL Redzone, you won’t miss a moment. Don’t forget to follow us on skysports.com/nfl, our Twitter account @SkySportsNFL & Sky Sports – on the go! 0:21 Jets quarterback Sam Darnold outruns everyone for a touchdown against the Broncos in Week Four Newton is playing on a one-year, prove-it deal in New England; after a good start, Newton contracted Covid-19 to see him miss some action and the team have lost their last four games to fall back to 2-5 on the season.Reinebold: “If they lose to the Jets, or lose again real soon, you’ve got to take a look at [back-up Jarrett] Stidham to know what you have.- Advertisement – “Based on the one-year contract they have with Cam, he’s probably not the long-term solution. He’s getting older and has accumulated a lot of hits to his body – this is a guy who, when he was in Carolina, really had to carry a football team on his shoulders and just got hit way too much.“And in defence of Cam, he had Covid and we really don’t know, there may still be lingering effects of that, because I don’t see the jump in his step we saw earlier in the season.“It’s hard for me to watch, because I’m a big Cam fan – always have been – and they have no talent around him; it’s a really tough situation for him in New England.”Daniel Jones (New York Giants) Will the winless New York Jets stick with young quarterback Sam Darnold beyond this season?
Will the winless New York Jets stick with young quarterback Sam Darnold beyond this season?

Kyle Allen: Washington quarterback dislocates left ankle in loss to New York Giants | NFL News

first_img– Advertisement – Kyle Allen will undergo an MRI on Monday; injury occurred as Allen was sacked by New York safety Jabrill Peppers, who apologised for the leg-whip; Smith deputised and threw his first touchdown since November 2018 Last Updated: 09/11/20 7:07am Allen’s injury made for an emotional moment for Alex Smith, who returned to action from his own serious leg injury last month after sustaining a compound fracture of his right tibia and fibula in November 2018.“A ton of emotions going on for me right then,” Smith said. “I knew Kyle was down and knew it was serious once he stayed down. You get ready to roll and all of a sudden you see them bringing out an air cast and the cart. I know that routine well. I’m trying to lock it in, but feeling for Kyle.” “I get it. I’ve been there in that situation. Peppers is a heck of a football player. He plays 100 miles an hour.” Washington Football Team quarterback Kyle Allen dislocated his left ankle and sustained a small fracture during the first quarter of his team’s 23-20 loss to the New York Giants on Sunday.Allen suffered what is expected to be a season-ending injury with 1:04 remaining in the first quarter and is set to undergo an MRI scan on Monday.The injury occurred as he was sacked by New York safety Jabrill Peppers, who apologised for the leg-whip and insisted there was no intent to injure Allen. Peppers was handed a roughing the passer penalty. Alex Smith threw his first touchdown pass in almost two years on Sunday Alex Smith threw his first touchdown pass in almost two years on Sunday

Apple to Launch M1-Powered 14-Inch, 16-Inch MacBook Pro Laptops in 2021 and New Mac Pro: Report

first_imgApple could reportedly be launching new 14-inch and 16-inch MacBook Pro laptops, all powered by its new in-house M1 chip, in 2021. According to a report, the Cupertino company could also be looking at launching a 24-inch iMac as well as a smaller Mac Pro workstation in the coming year. Unveiling the M1 SoC at the ‘One More Thing’ event on November 10, Apple introduced refreshed versions of MacBook Air, MacBook Pro 13-inch, and Mac mini powered by its new silicon.According to a report by IT Home, Apple could launch two MacBook Pro laptops powered by its new M1 chip. The new lineup is expected to comprise a new 14-inch MacBook Pro and a refreshed 16-inch MacBook Pro. Presently, the 16-inch MacBook Pro is listed on Apple Store with Intel processors. The 13-inch MacBook Pro, on the other hand, is listed with both M1 chip and Intel processor options. The new M1-powered entry-level MacBook Pro was announced alongside Apple silicon-based MacBook Air and Mac mini. The report also suggests that the purported 14-inch and 16-inch MacBook Pro could come with Mini-LED display. The two laptops are expected to launch sometime around the third quarter of 2021.- Advertisement – The publication also hinted at the possible launch of a 24-inch iMac, expected to be made official by the end of this year or in the first quarter of 2021. At present, iMac is listed on Apple Store in two sizes – 21.5-inch and 27-inch. If the new iMac releases, it will place in the middle of the two existing machines. The report also suggested the launch of a smaller Mac Pro. Expected to be about half the size of the regular Mac Pro but with a similar design, it isn’t known yet if the new workstation will replace the original or be an additional variant. No release date is known for the rumoured new Mac Pro either.The newly announced M1-powered MacBook Air, MacBook Pro 13-inch, and Mac mini are set to start shipping from November 17.Are iPhone 12 mini, HomePod mini the Perfect Apple Devices for India? We discussed this on Orbital, our weekly technology podcast, which you can subscribe to via Apple Podcasts, Google Podcasts, or RSS, download the episode, or just hit the play button below.- Advertisement – – Advertisement –last_img read more

Marcus Rashford, Conor Coady to miss England’s Nations League double-header | Football News

first_img“Meanwhile, Rashford’s arrival into camp had initially been delayed to allow for further assessment on an injury sustained last weekend but the Manchester United forward will now not meet up.”On his withdrawal, Wolves skipper Coady said he is “absolutely gutted” to have to pull out of the squad.- Advertisement – preview image 3:17 Highlights of the friendly between England and the Republic of Ireland from Wembley Stadium. Although the 27-year-old has tested negative twice with the contact coming prior to meeting up with the England squad, he still has to isolate in line with Government guidelines.Meanwhile, Manchester United’s Marcus Rashford misses out with a shoulder injury sustained during the win over Everton on Saturday.In a statement, the Football Association said: “Coady has been forced to self-isolate having discovered he had inadvertently come into contact with somebody prior to camp who has tested positive for Covid-19 via an NHS Test and Trace alert.- Advertisement – “The Wolverhampton Wanderers defender had returned two negative tests as part of The FA and UEFA’s protocol but, in line with UK Government guidelines, has to adhere to a period of self-isolation. Conor Coady and Marcus Rashford will miss England’s Nations League double-header against Belgium and Iceland.Wolves defender Coady has been forced to withdraw and isolate after being identified as a close contact to someone who has tested positive for coronavirus via track and trace.- Advertisement – Southgate added in his post-match press conference following the 3-0 win over Republic of Ireland: “To lose both is disappointing. We had some doubts about Marcus following the weekend, we hoped he might progress but that hasn’t happened.“For Conor, it’s one of those weird ones where he has to isolate when he’s more than likely not at risk. I think we’re OK on numbers. We think we’ve got the cover, but let’s hope that is the case.”England face Belgium in Leuven on Sunday before hosting Iceland at Wembley on Wednesday in the final two games of their Nations League group. “I contracted and recovered from the virus myself back in March, and have tested negative twice in camp, but of course it is important that I abide by the rules set by the government and observe a period of self-isolation,” the defender said.“It’s so frustrating to have to miss games because of this, but these are the rules that are set out and the most important thing is to make sure my team-mates are not put at risk.“My next priority will be to keep my fitness and hope I can be back and available for selection for the next Wolves fixture.“For now, I will be supporting the lads from afar and I want to wish them all the very best of luck for the next two games.” Conor Coady celebrates scoring his first England goal against WalesImage:Conor Coady has been forced to withdraw from the England squad due to coronavirus protocols – Advertisement –last_img read more

Will Smith Shares ‘Fresh Prince of Bel-Air’ Reunion Trailer

first_img“You’ve probably seen the picture. I posted it a month ago, me with the whole Fresh Prince cast … but you’re not ready for this trailer,” Smith tells the camera. “Happy Thanksgiving. Yes, thank you, Will, you’re welcome.”Will Smith Shares 1st Look at Fresh Prince of Bel-Air Reunion in New Trailer 1The cast of the Fresh Prince of Bel-Air Reunion YouTubeThe two-minute clip featured series regulars Smith, Tatyana Ali, Karyn Parsons, Joseph Marcell, Daphne Maxwell Reid and Alfonso Ribeiro reuniting with recurring costar DJ Jazzy Jeff in the Banks’ living room.The group remembered the on-screen chemistry between “playmates” Smith and Ribeiro, 49, and the “Friday night party” vibe that the cast had during tapings. Fresh Prince of Bel-Air aired for six seasons from 1990 to 1996.- Advertisement – – Advertisement – The trailer ends with Janet Hubert, who originally played Aunt Vivian, returning to the set. Hubert, 64, left the show in 1993 after she and Smith had difficulties working together. Reid took over the role for the final three seasons.“I couldn’t celebrate 30 years of Fresh Prince without Janet,” Smith says before Hubert is seen walking around the backlot while the cast looks shocked.Hubert told TMZ in 2011 that she had no plans to reunite with Smith because of their feud.“There will never be a reunion … as I will never do anything with an a–hole like Will Smith,” she said at the time. “This constant reunion thing will never ever happen in my lifetime unless there is an apology, which he doesn’t know the word.”Smith, for his part, appeared to feel better about their relationship in February 2016 when he praised Hubert’s work on the show.“I think that both of the Aunt Vivs were really, really fantastic,” Smith said during an interview with BBC Radio 1Xtra. “I think when you make a show, anytime you make a change, it’s going to be excruciating and painful. I think that Janet Hubert Whitten brought a really powerful dignity to the show.”The Fresh Prince of Bel-Air reunion airs on HBO MAX on Thursday, November 19.Listen to Watch With Us to hear more about your favorite shows and for the latest TV news! However, some of the cast had some reservations about joining the show. Reid, 72, recalled not wanting to do a sitcom with a “rapper” while Jeff, 55, wasn’t on board for the project at first because he didn’t consider himself an actor.Will Smith Shares 1st Look at Fresh Prince of Bel-Air Reunion in New TrailerAlfonso Ribeiro and Will Smith YouTubeThe cast also paid tribute to James Avery, who portrayed patriarch Philip Banks on the NBC sitcom. Avery died at the age of 68 in December 2013 following complications from open-heart surgery.“James Avery was this 6-foot-4 Shakespearean beast and I wanted him to think I was good,” Smith said before a clip played of the pair in an emotional scene. “I fall into his arms at the end of the scene and he’s holding me, and the shot pans off and he whispered in my ear, ‘Now, that’s acting.’”- Advertisement – Yo home to Bel Air! Will Smith dropped the first trailer for the Fresh Prince of Bel-Air reunion special, which featured the cast reminiscing about the iconic sitcom 30 years later.The Men in Black star, 52, shared the video via YouTube on Friday, November 13, which he prefaced with an introduction.- Advertisement –last_img read more

Trump eggs on primary challenge to GOP governor who acknowledged Biden’s win

first_imgRenacci’s beef with DeWine, whom he spent months running against in the 2018 gubernatorial primary before he switched to the Senate race, goes back much further than the aftermath of the 2020 election, though. Back in September of last year, Renacci argued that the state had seen little private-sector job growth during DeWine’s first six months in office, and the former congressman notably declined to rule out a primary bid. Renacci has also spent his 2020 attacking DeWine’s measures to combat the coronavirus pandemic, with him writing last month that the state was “committing economic suicide” under its current leadership.Renacci also used his weekend to trash DeWine on Twitter for recognizing the results of the election and for considering new restrictions on restaurants and bars as COVID-19 cases rise, and he called for voters to “Ditch DeWine.” However, Renacci wouldn’t say if he was considering taking on the governor himself, though he did add, “It’s always the right for citizens to primary or run for office if they believe change is necessary.”Ohio has become a rough state for Democrats over the last few years, but Renacci could give Team Blue more of an opening if he managed to take the nomination from DeWine. Renacci ran a weak campaign against Brown in 2018, and national Republicans never bothered to spend much money to aid him.- Advertisement – While DeWine, who served as Trump’s state co-chair, added, “The White House, or the president and his campaign, has every right to go into court” and challenge the results, his admission that “Joe Biden is the president-elect” was not what Trump wanted to hear. Indeed, Media Matters’ Matthew Gertz noted that Trump’s tweet came just 39 minutes after Fox had aired a clip of DeWine’s comment.Campaign Action- Advertisement – Renacci also pissed off his party by loaning his campaign $4 million but never spending most of it (almost $3.5 million in loans were repaid to the candidate after the campaign was over), and he managed to attract unhelpful headlines like, “Jim Renacci failed to pay strip club owner for governor campaign flights.” Brown ended up winning 53-47, even as DeWine prevailed 50-47 and the GOP swept every other partisan statewide race that same evening.Georgia Runoffs● GA-Sen-A, GA-Sen-B: Republican Sen. David Perdue recently launched his first TV spot of the Jan. 5 runoff, which ties Democrat Jon Ossoff to House Speaker Nancy Pelosi and Senate Minority Leader Chuck Schumer. The commercial shows a clip of Schumer saying, “Now we take Georgia, then we change America,” footage that conservatives have already made plenty of use of.Ossoff, meanwhile, is connecting Perdue to Donald Trump, who is the first Republican presidential nominee to lose Georgia since George H.W. Bush in 1992, in the Democrat’s second runoff spot. The ad, which is similar to one that ran in the first round of voting, features audio of both Trump and Perdue using almost identical language to downplay the coronavirus as a chart shows its death toll skyrocketing.- Advertisement – – Advertisement – Meanwhile in the special election, Democrat Raphael Warnock is out with two new spots against appointed GOP incumbent Kelly Loeffler. One ad slams the stock transactions made in Loeffler’s name before the stock market crashed in March, while Warnock uses the other commercial to push back on the senator’s attacks against him.Warnock says in the latter piece, “I believe that in the greatest nation in the world, people should have affordable healthcare. That Georgians who work hard every day deserve a livable wage, and that seniors ought to be able to afford the costs of prescription drugs.” He concludes, “Kelly Loeffler may think that’s radical, I think it’s common sense.”Senate● MO-Sen: Republican incumbent Roy Blunt’s team recently confirmed that he would seek a third term in 2022, and there’s no obvious Democratic opponent on the horizon. Abe Rakov, a longtime aide to 2016 nominee Jason Kander, told the Kansas City Star over the weekend that Kander would not seek a rematch in two years.● NH-Sen, NH-Gov: Former Republican Sen. Kelly Ayotte did not rule out seeking a rematch with Democratic incumbent Maggie Hassan when she was asked about the idea on Friday. Ayotte, who sits on the board of the conservative group Winning for Women, told Roll Call, “I’m very happy with what I’m doing right now. So I’m not focusing on running for office.” There has also been some speculation that Ayotte could run to succeed Gov. Chris Sununu if he takes on Hassan instead.Gubernatorial● VA-Gov: Former Democratic Gov. Terry McAuliffe has been talking about running for his old job next year for a while, and Axios reported on Sunday that he’s told friends that he plans to go for it “in the coming weeks.” McAuliffe has not yet said anything publicly about his 2021 plans, though his spokesperson confirmed last week that the former governor would not be seeking any posts in the Biden administration.The Democratic field already consists of Lt. Gov. Justin Fairfax, state Sen. Jennifer McClellan, and Del. Jennifer Carroll Foy, and another potential candidate is also expressing interest in seeking the nomination. Reporter Brandon Jarvis tweeted on Saturday that Del. Lee Carter, a self-described socialist, “believes there is a path to victory for him and he is strongly considering running.” Carter soon replied with a GIF of The Office’s Dwight Schrute captioned, “It’s True.” (Yes, we do indeed live in a world where politicians communicate their interest in higher office through GIFs.)House● MS-04: On Thursday, Republican Rep. Steven Palazzo’s campaign said that he was under investigation by the Office of Congressional Ethics for allegedly misusing nearly $200,000 in campaign funds. Palazzo’s treasurer argued that the congressman had done nothing wrong, and added, “I think in the final analysis, it’s going to be a disgruntled employee and a sore loser that is driving this thing.”The probe stems from a March complaint from the nonpartisan Campaign Legal Center, which accused the congressman’s campaign of spending $60,000 in rent in 2018 and 2019 for a Palazzo-owned farm they did not ultimately use; CLC also said that the campaign paid more than three times as much rent per month during this time than the state’s other three congressmen combined. As Roll Call‘s Chris Marquette explains, “House rules allow members of Congress to lease property to their campaigns if there is a bona fide campaign need for the space and specify that the campaign cannot pay more than fair market value.”The CLC also said that Palazzo’s campaign paid $128,000 since he took office in 2011 to an accounting firm run by his now-former wife, who is not a certified public accountant; the couple divorced in 2016, but the campaign continued to make the payments. Marquette writes, “If a family member wants to sell services to a lawmaker’s campaign, there needs to be a bona fide campaign rationale for it and it cannot be more than fair market value, according to federal law and House rules.”Legislative● AK State Senate: While Alaska Republicans maintained their 13-7 majority in the state Senate, Democrats are hoping that GOP infighting will give them a chance to form a governing coalition. The baker’s dozen of Republicans met on Friday but failed to decide on a new Senate president, though the members said they were still confident they’d be able to work out an agreement for an all-GOP ruling majority.Called RacesA handful of major races remain uncalled, and Daily Kos Elections is tracking them here.● CA-39: The AP called this contest on Friday for Republican Young Kim, who defeated freshman Democratic Rep. Gil Cisneros in their rematch from two years ago.● UT-04: Republican Burgess Owens secured a pickup for his party on Monday when freshman Democratic Rep. Ben McAdams conceded defeat; the AP called the contest a short time afterwards.● AK Ballot: The Associated Press has called a defeat for Measure 1, which would have increased the state’s fuel production tax; the referendum lost 58-42.Grab Bag● Deaths: Former Iowa Sen. Roger Jepsen, a Republican who won his only term in a big 1978 upset, died Friday at the age of 91. Jepsen, who was a former lieutenant governor, took on freshman Democratic Sen. Dick Clark during Jimmy Carter’s midterm year, and he looked like the underdog during the entire campaign. The New York Times notably called Jepsen “a rather plodding campaigner with a tendency to get tangled up in positions that he repeatedly had to clarify or back away from,” while it said Clark had “reputation for being both articulate and tireless on the hustings.”National Right to Life, though, made Clark its top national target, and it found a willing ally in the anti-abortion challenger. Jepsen ended up defying the polls and winning 51-48, a result that was attributed to his performance among anti-abortion Catholic voters who had yet to fully align themselves with the Republican Party. Clark’s campaign manager afterwards blamed his defeat on the 300,000 pamphlets that were circulated in churches by anti-abortion forces the Sunday before the election.Six years later, though, Jepsen faced a tougher contest from five-term Rep. Tom Harkin. The Democrat began the 1984 contest with a wide lead over Jepsen at a time when the economy, especially in farming areas, was suffering. However, the race turned very close and ugly, and the lead would shift multiple times.Harkin, notably, went after Jepsen after the news broke that he’d joined a spa in 1977 that listed “nude modeling, nude encounters and nude rap sessions” as offerings; the spa was shuttered three months after Jepsen joined it after authorities raided it for prostitution. Jepsen defended himself by saying that he’d ventured there once out of “curiosity and weakness” and never went back.Harkin took a decisive lead in the polls late in the campaign, and despite Jepsen’s attempts to once again use abortion as a wedge issue, the Democrat didn’t lose his advantage. Ronald Regan ended up carrying Iowa by a 53-46 margin during his 49 state landslide, but Harkin’s strong showing in farming areas that were still struggling helped propel him to a 55-44 win. Reagan appointed Jepsen afterwards to the National Credit Union Administration, but the former senator never sought office again.last_img read more

Sanofi reports results for H5N1 vaccine with adjuvant

first_imgMay 12, 2006 (CIDRAP news) – In a human trial in France, an experimental H5N1 avian influenza vaccine with an adjuvant showed modestly better performance at a lower dose compared with a similar H5N1 vaccine that was tested earlier in the United States.The new study, published in this week’s The Lancet, showed an immune response in 67% of patients receiving two doses of 30 micrograms (mcg) of the vaccine plus an adjuvant. An accompanying commentary, however, pointed out several obstacles that need to be addressed before an effective vaccine can be mass-produced.The vaccine is manufactured by Sanofi Pasteur, a subsidiary of France-based Sanofi Aventis. It is an inactivated, split-virion strain of H5N1 known as Vietnam/1194/2004. The company reported preliminary results of the trial in December 2005.The study involved 300 adults (aged 18 to 40), divided into three groups receiving 7.5, 15, or 30 mcg of the vaccine, plus three groups receiving the same doses of vaccine combined with an aluminum hydroxide adjuvant. Four of the groups comprised 50 people, one 49, and one 51. Study investigators included two from Sanofi Pasteur, including the senior author.Each patient received the vaccine on the first day of the study and 21 days later. All patients were assessed on day 21 and day 42 for immune response.On day 42, of those receiving 30-mcg doses with adjuvant, 67% were seropositive (95% confidence interval, 52% to 79%), compared with 52% of the 30-mcg group without adjuvant. Percentages for both 15-mcg groups were 44%, and those for the 7.5-mcg groups were 43% and 28% without and with an adjuvant, respectively.In the US study published in March, 451 adults received two doses of 7.5, 15, 45, or 90 mcg of another H5N1 vaccine made by Sanofi, all without an adjuvant. Of the 99 volunteers who received two 90-mcg doses, 54% developed H5N1 antibodies. This compared with 43% in the 45-mcg group, 22% in the 15-mcg group, and 9% in the 7.5-mcg group. The vaccine was based on a different human isolate of H5N1 than the one used in the French study. The study was published in the New England Journal of Medicine.In the new study, some seroconversion was evident in each of the groups at day 21, after only one dose of the vaccine was administered. Seropositivity was defined as a titer of 32 or greater. The patients had no serious adverse events, few severe reactions, and no oral temperatures higher than 38°C (100.4°F).The authors conclude, “Our two-dose 30 mcg inactivated H5N1 pandemic vaccine is safe and immunogenic. We also noted encouraging responses with lower doses of antigen.”In an accompanying commentary, however, Suryaparkash Sambhara, DVM, PhD, from the Centers for Disease Control and Prevention, and Gregory A. Poland, MD, of the Mayo Clinic in Rochester, Minn., emphasize that more hurdles need to be cleared. They write that the study results, though more promising than in the earlier US study, leave much to be desired.”The results of these two early clinical trials,” they write, “clearly indicate that we still do not have a highly immunogenic vaccine to use against H5N1 influenza.” They cite the following factors:It is unknown whether the antibodies induced by the vaccine would sufficiently protect people from a pandemic virus.No published reports indicate how this “clade 1” vaccine will cross-react with other H5N1 subtypes.The regimen of two 30-mcg doses is still high and would limit the number of doses available at current manufacturing capacity. (Seasonal flu vaccination typically consists of one 15-mcg dose.)No data exist on the vaccine’s effect on immunocompromised people, such as the young or old.According to the study’s authors, “In a pandemic situation, the aim will be to immunize a maximum number of people to protect them against mortality and severe disease. The level of postvaccination antibodies needed to achieve this protection is not known. Limited manufacturing capacity implies the need to adapt dose-sparing strategies. The challenge, therefore, is to find the appropriate compromise between individual protection and protection from a population perspective.”Bresson J-L, Perronne C, Launay O, et al. Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase 1 randomised trial. Lancet 2006 (early online publication, May 11) [Abstract]Sambhara S, Poland GA. Avian influenza vaccines: what’s all the flap? (Commentary). Lancet 2006 (early online publication, May 11)See also:Dec 15, 2005, CIDRAP News story on preliminary results of French study”Sanofi says H5N1 vaccine with adjuvant may go further”New England Journal of Medicine report on earlier H5N1 vaccine studyhttp://content.nejm.org/cgi/content/full/354/13/1343March 30 CIDRAP News story “H5N1 vaccine trial shows limited benefit”last_img read more

The Port Authority of Split conducted an action of intensified maritime traffic control

first_imgThe Port Authority of Split in coordination with the associated port offices (Omis, Baska Voda, Makarska, Podgora, Igrane Milna, Bol, Jelsa, Hvar O. Solta, Pakleni islands, Trogir, Krknjaši, Maslinica) carried out an action of enhanced maritime traffic control, code name “SAFE NAVIGATION 2017”.The intensified surveillance action was held yesterday, August 2, when the officers of the Split Harbor Master’s Office conducted 10.00 inspections between 19.00:62 and 41:17, which included four ships, XNUMX domestic boats and yachts, and XNUMX foreign boats and yachts.Kako ističu iz Lučke kapetanije Split, poduzetom akcijom pojačanog nadzora zabilježen je ukupno 31 pomorski prekršaj za što su naplaćene kazne u iznosu 39.886,00 kuna, uz četiri izrečene opomene prema prekršiteljima. “Naplaćeni prekršaji u najvećem dijelu odnose se na glisiranje zbog čega je sankcionirano 8 sudionika u pomorskom prometu, jedna prekršajna kazna izrečena je zbog brze vožnje u luci, zbog prekomjernog ukrcaja putnika 17 prekršaja, zbog nedostatka člana posade 3 prekršaja, a zbog neposjedovanja propisane dokumentacije na plovilima sankcionirane su dvije osobe.” They point out from LKS and add that the implementation of the action of enhanced safety control of navigation will continue in the period of increased maritime traffic (during the tourist season), primarily in order to intervene in maritime accidents and incidents, ie to sanction violators.last_img read more

Vinkovci started the process of branding Vinkovci as a tourist destination

first_imgThe Tourist Board of the city of Vinkovci has started the process of branding Vinkovci as a tourist desirable destination.The need for branding was also recognized by the CNTB, which, according to the CNTB’s Public Invitation for tourist boards in underdeveloped tourist areas, granted support in the amount of HRK 60.000,00, while the rest of the necessary funds will be provided from the budget of Vinkovci. The Institute for Tourism is in charge of drafting the branding project, which has so far been involved in drafting various documentation in Vukovar-Srijem County, as well as in drafting the Master Plan for Tourism Development in the city of Vinkovci.The goal of the project is to raise the level of recognizability of Vinkovci in the tourist market and give guidelines for creating an offer that will ‘revive’ the brand and attract more guests, and the document will analyze the current state of marketing in the destination, develop a brand concept and promotion strategy. ” Branding is a process, it’s not just a logo and slogan. It is a long-term process because we give the brand a promise that must be delivered to the destination. The whole destination has to tell the story of that brand. This document is the guideline and core of the entire brand, and thus the starting point for all day promotional activities and the development of the entire tourist offer that should be adapted to the uniqueness that Vinkovci offers and what distinguishes them from other destinations.”Said the project manager, Ph.D. Snježana Boranić Živoder from the Institute of Tourism.For the needs of the project, two surveys were conducted. The first, which referred to the survey of perceptions about the city of Vinkovci among the people of Zagreb, showed that the first associations with Vinkovci were: Vinkovci Autumns, Slavonia, Slavonians, East and the song ‘Come to Vinkovci’. Among the predefined associations, the respondents most often singled out: Vinkovci Autumn, Slavonia, NK Cibalia, gastronomy and railway. The people of Zagreb mostly agree with the claims that ‘Vinkovci is an experience of Slavonia’, ‘City of tradition and customs’ and ‘city of rich cultural and historical heritage’. The most associated with Vinkovci are gold, yellow and green.Another study showed that Vinkovci has been mentioned about 2 times in the online media in the last four months, about 900 times in the context of tourism. They are mostly mentioned in Croatian, less in English and very modestly in German and Slovenian.This is the first foundation for the strategic and sustainable development of a tourist destination, of course if the document is made with quality and does not remain somewhere in the drawer to collect dust. The project is expected to be completed by the end of November 2017.Related news:VINKOVCI AS THE OLDEST CITY IN EUROPE MUST BE THE MAIN STAR OF EUROPEAN TOURISM,VINKOVCI AS THE OLDEST CITY IN EUROPE MUST BE THE MAIN STAR OF EUROPEAN TOURISMlast_img read more